公共卫生 公共卫生
Theodore M DeConne1, Cynthia Suerken2, Megan E Lipford1
1Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
结构性动脉硬,而不是负载依赖性硬,与较低的认知功能和大脑异常有关. 对动脉硬的干预措施可以保持认知和大脑健康.
科学领域:
- 心血管健康 心血管健康
- 神经学 神经学
- 衰老研究研究 衰老研究
背景情况:
- 最近的进展使得负载依赖性 (LD-PWV) 和结构性 (S-PWV) 动脉硬度与总脉冲波速度 (T-PWV) 的区分成为可能.
- 动脉硬是阿尔茨海默病和阿尔茨海默病相关痴呆症 (AD/ADRD) 的新兴风险因素.
- 之前的研究表明S-PWV,但不是LD-PWV,可能与认知衰退和AD生物标志物相关.
研究的目的:
- 测试假设较高的S-PWV,而不是LD-PWV,与较低的认知功能有关.
- 用MRI成像生物标志物研究S-PWV和LD-PWV之间的关系.
- 检查动脉硬度测量与血和PETAD生物标志物的相关性.
主要方法:
- 在516名参与者 (平均年龄为70.4岁) 中测量了关节-关节脉冲波速度 (PWV).
- 使用参与者特定模型计算S-PWV和LD-PWV.
- 评估了认知功能,脑部MRI和AD生物标志物 (血和PET).
主要成果:
- 较高的T-PWV和S-PWV与较低的全球认知功能相关.
- 较高的LD-PWV与减少白质完整性和脑血流有关.
- 较高的T-PWV和S-PWV与增加的灰质自由水和白质异常有关.
结论:
- 结构性动脉硬与认知障碍和大脑结构异常有关.
- 与血压相关的动脉硬会影响白质的完整性和血液流动.
- 针对动脉硬可能是一种维持认知和脑血管健康的策略.
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