公共卫生 公共卫生
Dereck L Salisbury1, Feng Vankee Lin2, Fang Yu3
1University of Minnesota, Minneapolis, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
动员框架改善了多地点阿尔茨海默病 (AD) 试验中的干预出席率和安全性. 这种实施策略对于早期和多地点研究至关重要.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 临床试验 临床试验
背景情况:
- 多部位阿尔茨海默病 (AD) 行为干预试验在剂量递送和认知结果方面面临挑战.
- 针对阿尔茨海默病的行为和生活方式干预措施的实施框架 (MOBILIZE) 是为了解决这些实施问题而开发的.
研究的目的:
- 通过使用MOBILIZE框架,系统评估3个地点有氧运动和认知训练 (ACT) 试验的实施结果.
- 评估三个不同的地点的ACT试验中的查,干预遵守和安全性.
主要方法:
- 该研究使用了MOBILIZE框架,重点关注以人为中心的护理原则.
- 实施结果包括查时间,干预坚持 (出席率,疗程剂量) 和与研究相关的不良事件.
- 从明尼苏达大学 (UMN),罗切斯特大学 (UR) 和亚利桑那州立大学 (ASU) 的146名参与者收集了数据.
主要成果:
- 从查到招生的平均时间为98天.
- 干预的坚持因地点而异,认知会话的坚持较低 (51.5±26.2%) 与炼会话的坚持相比 (71.7±30.8%).
- 发生了10个与研究相关的不良事件,不同地点没有显著差异.
结论:
- 在ACT试验中,MOBILIZE框架促进了高干预出席率和安全性.
- 这种框架对于阿尔茨海默病早期和多地点干预试验特别有益.
- MOBILIZE有助于标准化AD的行为干预措施,改善试验一致性和结果.
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