公共卫生 公共卫生
Yun Jeong Hong1, Si-Baek Lee2, Seong Hoon Kim3
1Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of (South).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
最佳的剂量和对抗痴呆症药物的坚持显著改善了阿尔茨海默病 (AD) 患者的长期结果. 保持高的药物占有率 (MPR) 和标准剂量可以减少痴呆症的进展,住院和死亡率.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔茨海默病 (AD) 管理涉及抗痴呆药物.
- 有限的研究存在于与药物剂量和患者坚持相关的长期结果.
- 研究这些因素对于优化AD患者护理至关重要.
研究的目的:
- 评估抗痴呆药物剂量和药物遵守对AD患者长期临床结果的影响.
- 根据治疗策略,比较中度至重度痴呆,住院和死亡的发病率.
- 利用来自国家健康保险服务 (NHIS) 的大数据进行强大的分析.
主要方法:
- 韩国NHIS高级队列 (NHIS-SC) 基于人口的队列分析 (2009-2022年).
- 包括486,398名在2010年至2016年期间被诊断为AD患者.
- 根据药物持有率 (MPR ≥70%与<70%),药物剂量 (最佳与低) 和前3年整体最佳治疗 (MPR ≥70%和最佳剂量) 进行分类.
主要成果:
- 符合最佳药物规范的患者 (MPR ≥70%) 与遵守规范较低的患者相比,表现出更好的长期结果.
- 最佳剂量组表现出优越的长期临床结果,而不是低剂量组.
- 最佳治疗 (高MPR和最佳剂量) 与明显更好的结果相关,而不是次优治疗.
结论:
- 在AD痴呆症患者的长期临床结果受到最佳抗痴呆药物剂量和在诊断后最初3年内的药物遵守的影响.
- 坚持和适当的剂量是管理AD进展和改善患者预后的关键因素.
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