公共卫生 公共卫生
Jillian S Baker1, Lauren P MacConnachie1, Alexis Reeves2
1University of Michigan, Ann Arbor, MI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
老年妇女的步行速度更快与随着时间的推移更好的认知功能有关. 这项研究发现了双向关系,强调需要考虑参与者退出研究的必要性.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 身体功能,特别是步行速度,在绝经后的女性下降.
- 已知步行速度和认知之间存在联系,但纵向数据有限.
- 对老年人的前性研究可能会导致参与者离开研究.
研究的目的:
- 量化行走速度与女性认知功能之间的纵向关联.
- 在前性研究中考虑损失到后续偏差.
- 分析来自全国妇女健康研究 (SWAN) 的数据.
主要方法:
- 利用了来自多民族SWAN队列的数据.
- 在两个时间点 (V13和V15) 评估行走速度和认知功能 (工作记忆,处理速度,口头记忆).
- 使用线性回归和反向概率加权来调整共变量和损失后跟踪.
主要成果:
- 在V13时更快的步行速度预测了在V15时更高的认知z分数 (β=0.20).
- 在加权模型中,V13时更高的认知z-score预测了V15时更快的步行速度 (β=0.022).
- 考虑到损失到后续的权重模型显示出比未加权模型更强的双向关联.
结论:
- 在女性中,随着时间的推移,步行速度和认知表现之间存在双向关系.
- 如果不考虑选择偏差,可能会低估这些关联的强度.
- 需要对特定的认知领域和身体功能措施进行进一步的研究.
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