Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Prognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy.

International journal of medical sciences·2026
Same author

Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats.

The Journal of endocrinology·2026
Same author

Characterization of gut microbiota in wild Asian elephants (Elephas maximus) from five forests across Thailand.

Scientific reports·2026
Same author

Roles of Metabolomics in Allergic Rhinitis: From Cell to Bedside Investigations.

International journal of molecular sciences·2026
Same author

Stage-Associated Subgingival Dysbiosis Across the Periodontal Disease Spectrum in a Thai Cohort.

Journal of clinical periodontology·2026
Same author

Inhibiting Purinergic Receptor (P2X7R) Alleviates Depression- and Anxiety-Like Behaviors in Obese Rats With Immune Challenge.

Acta physiologica (Oxford, England)·2026

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Titikorn Chunchai1,2, Hiranya Pintana1,2, Patcharapong Pantiya1,2

  • 1Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

乳杆菌reuteri KUB-AC5益生菌的管理通过减少代谢问题和氧化应激改善了肥胖大鼠的认知功能. 这凸显了它在治疗代谢和神经退行性疾病方面的潜力.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 微生物学 微生物学
  • 代谢科学 代谢科学

背景情况:

  • 慢性高脂肪饮食 (HFD) 的消费导致肠道失调,内毒素,以及认知障碍.
  • 像Lactobacillus paracasei HII01这样的益生菌对肥胖大鼠的代谢和认知健康有明显的益处.
  • 乳杆菌reuteri KUB-AC5对肥胖,胰岛素抵抗性大鼠这些参数的特定影响仍未得到研究.

研究的目的:

  • 研究Lactobacillus reuteri KUB-AC5对肥胖,胰岛素抵抗性大鼠的认知功能,代谢障碍和大脑线粒体功能的影响.
  • 为了确定L. reuteri KUB-AC5是否可以减轻HFD引起的负面健康结果.

主要方法:

  • 雄性Wistar大鼠在24周内被食正常饮食 (ND) 或HFD.
  • 从第13周开始,小组接受了车辆或L. reuteri KUB-AC5 (10^8 CFU/天) 12周.
  • 评估了认知功能,代谢标志物和大脑线粒体功能.

主要成果:

  • HFD增加了体重,内脏脂肪,胆固醇,胰岛素,HOMA-IR和血清MDA.
  • 在HFD大鼠中,L. reuteri KUB-AC5治疗显著降低了体重,胰岛素,血清MDA和HOMA-IR.
  • 益生菌治疗改善了大脑线粒体功能,增加了树突脊柱密度,并减轻了HFD老鼠的认知衰退.

结论:

  • L. reuteri KUB-AC5的使用减轻了胰岛素耐药性肥胖大鼠的认知衰退.
  • 益生菌减轻代谢干扰,减少氧化压力,增强大脑线粒体功能和神经元可塑性.
  • L. reuteri KUB-AC5显示出作为代谢和神经退行性疾病治疗剂的潜力.