基础科学和病原发生学
Titikorn Chunchai1,2, Hiranya Pintana1,2, Patcharapong Pantiya1,2
1Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
乳杆菌reuteri KUB-AC5益生菌的管理通过减少代谢问题和氧化应激改善了肥胖大鼠的认知功能. 这凸显了它在治疗代谢和神经退行性疾病方面的潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢科学 代谢科学
背景情况:
- 慢性高脂肪饮食 (HFD) 的消费导致肠道失调,内毒素,以及认知障碍.
- 像Lactobacillus paracasei HII01这样的益生菌对肥胖大鼠的代谢和认知健康有明显的益处.
- 乳杆菌reuteri KUB-AC5对肥胖,胰岛素抵抗性大鼠这些参数的特定影响仍未得到研究.
研究的目的:
- 研究Lactobacillus reuteri KUB-AC5对肥胖,胰岛素抵抗性大鼠的认知功能,代谢障碍和大脑线粒体功能的影响.
- 为了确定L. reuteri KUB-AC5是否可以减轻HFD引起的负面健康结果.
主要方法:
- 雄性Wistar大鼠在24周内被食正常饮食 (ND) 或HFD.
- 从第13周开始,小组接受了车辆或L. reuteri KUB-AC5 (10^8 CFU/天) 12周.
- 评估了认知功能,代谢标志物和大脑线粒体功能.
主要成果:
- HFD增加了体重,内脏脂肪,胆固醇,胰岛素,HOMA-IR和血清MDA.
- 在HFD大鼠中,L. reuteri KUB-AC5治疗显著降低了体重,胰岛素,血清MDA和HOMA-IR.
- 益生菌治疗改善了大脑线粒体功能,增加了树突脊柱密度,并减轻了HFD老鼠的认知衰退.
结论:
- L. reuteri KUB-AC5的使用减轻了胰岛素耐药性肥胖大鼠的认知衰退.
- 益生菌减轻代谢干扰,减少氧化压力,增强大脑线粒体功能和神经元可塑性.
- L. reuteri KUB-AC5显示出作为代谢和神经退行性疾病治疗剂的潜力.
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