公共卫生 公共卫生
Pei-Chuan Ho1, Guerry M Peavy2, Victor W Henderson3
1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
阿尔茨海默病亚洲队列研究 (ACAD) 开发了一种文化敏感的数据收集包 (DCP),以改善亚裔美国人和亚裔加拿大人的阿尔茨海默病 (AD) 研究参与. 该协议有助于收集数据,以了解亚洲不同人口中的AD风险因素.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 解决亚裔美国人和亚裔加拿大人 (ASAC) 在阿尔茨海默病 (AD) 研究中的不足.
- 强调需要针对不同亚洲人口的文化和语言相适应的研究工具.
- 在中国,越南和韩国社区启动了ACAD研究,以调查AD风险因素.
研究的目的:
- 开发和实施一个文化和语言适合的数据收集包 (DCP) 用于AD研究.
- 通过解决潜在障碍,鼓励亚洲老年人参与阿尔茨海默病研究.
- 收集有关亚洲特定族群亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚裔亚洲亚裔亚裔亚洲亚裔亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲亚洲
主要方法:
- 由ACAD临床核心领导的DCP开发,涉及跨学科专家.
- 协议最初侧重于虚拟程序,以克服与流行病有关的限制.
- 与数据管理,培训和质量保证以及生物样本核心合作,以实现无管理和数据输入.
主要成果:
- DCP以广东语,韩语,普通话和越南语提供,涵盖人口统计,生活方式,认知,功能,精神病和病史.
- 神经学检查数据与DCP信息相结合,可以进行共识诊断 (正常控制,轻度认知障碍,痴呆症).
- 截至2025年1月,ACAD同意了1173名参与者,收集了885个样本,并完成了864个诊断.
结论:
- ACAD开发了DCP和样本采集协议,以弥补ASAC在AD研究中的代表性差距.
- 试点阶段展示了成功的虚拟评估,表明可行性和有效性.
- 计划在2025年春季扩大招聘,以进一步加强研究参与和数据采集.
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