公共卫生 公共卫生
Clémence Cavaillès1, Katie L Stone2, Yue Leng1
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
长时间的睡眠时间和睡眠开始后醒来 (WASO) 与认知能力下降有关,特别是在执行功能和注意力方面. 这些发现强调了在睡眠研究中评估特定认知领域的重要性.
科学领域:
- 老年学是一门学科.
- 睡眠科学 睡眠科学
- 神经科学是一个神经科学.
背景情况:
- 睡眠不足和昼夜节律障碍与认知能力下降和痴呆症风险有关.
- 关于客观睡眠测量,休息活动节奏 (RAR) 和特定认知领域的研究有限.
研究的目的:
- 调查客观睡眠指标,RAR参数和老年人的认知功能之间的关联.
- 检查睡眠和昼夜节律变量如何与执行功能,注意力,记忆和语言有关.
主要方法:
- 利用了Dormir研究中856名参与者 (≥50岁) 的7天手腕动图数据.
- 获得了客观睡眠指标 (持续时间,效率,WASO,SFI) 和RAR参数 (广度,尺度,缩,伪F).
- 评估认知领域 (执行功能,注意力,记忆,语言) 使用复合z分数和调整为共变量的线性回归模型.
主要成果:
- 长时间睡眠时间 (>8小时) 与执行功能和注意力较差相关.
- 睡眠开始后长时间的清醒 (WASO;>62.3分钟) 与执行功能,注意力和记忆力的缺陷有关.
- 与认知正常个体相比,轻度认知障碍 (MCI) 或痴呆症的参与者表现出更差的睡眠效率,更长的WASO,更高的SFI和改变的RAR参数.
结论:
- 长时间的睡眠时间和增加的WASO是执行功能和注意力的认知缺陷的重要预测因素.
- 这些发现强调了需要在睡眠和认知研究中进行特定领域的认知评估.
- 客观的睡眠和昼夜节律的测量提供了宝贵的见解,对认知健康在衰老.
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