Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

TAVR in a Small Surgical Bioprosthesis With a Kinked Aortic Graft Using an Intra-Annular Self-Expanding Valve.

JACC. Case reports·2026
Same author

Real-world experience with sodium-glucose cotransporter 2 inhibitors in adults with Fontan circulatory failure.

Frontiers in cardiovascular medicine·2026
Same author

Imaging findings in Fontan-associated liver disease: Results of a single center study.

International journal of cardiology. Congenital heart disease·2026
Same author

Efficacy of Non-invasive Ventilation Compared to Intubation in Pediatric Acute Respiratory Failure: A Meta-Analysis.

Cureus·2026
Same author

Corrigendum to "Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons" [Mol. Cell. Endocrinol. 384 1-2 (2014) 52-60].

Molecular and cellular endocrinology·2026
Same author

Publisher Correction: Integrated Liquid Biopsy and Tumor Tissue Genomic Profiling of Appendiceal Cancer: cfDNA Burden, Mutation Landscapes, and Clinical Outcomes.

Annals of surgical oncology·2026
Same journal

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Amy Christensen1, Cassandra J McGill1, Ali Zaidi1

  • 1University of Southern California, Los Angeles, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

长寿治疗,如禁食模仿饮食 (FMD) 和17α-雌激醇 (17αE2) 减少了老鼠阿尔茨海默氏病 (AD) 神经病理. 这些干预措施在存在APOE4基因时显示出最强的保护作用,APOE4基因是AD的关键风险因素.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 衰老研究研究 衰老研究

背景情况:

  • 老龄化是阿尔茨海默病 (AD) 的主要危险因素.
  • 阿波利波蛋白E4 (APOE4) 基因基因是阿尔茨海默氏病的重要遗传风险因素,与寿命减少有关.
  • 受衰老影响的途径和APOE4与阿尔茨海默病有关,这表明长寿干预措施可能会重新用于阿尔茨海默病治疗.

研究的目的:

  • 在阿尔茨海默病小鼠模型中研究两种长寿干预措施的疗效,即禁食模仿饮食 (FMD) 和17α-雌激醇 (17αE2).
  • 确定口病和17αE2对AD神经病理学的独立和联合影响.
  • 评估阿波利波蛋白E (APOE) 基因型 (APOE3与APOE4) 对治疗疗效的影响.

主要方法:

  • 使用EFAD小鼠 (人类APOE3或APOE4与5xFAD AD模型交叉).
  • 给16个月大的雄性小鼠用17α-雌激醇 (17αE2) 和/或循环禁食模仿饮食 (FMD) 进行了9周的治疗.
  • 在四个组中比较了结果:车辆 + 随意饮食,车辆 + FMD,17αE2 + 随意饮食和17αE2 + FMD.

主要成果:

  • 无论是17αE2还是口都独立地减少了阿尔茨海默病的神经病理学,这种方式取决于APOE基因型.
  • 对口病和17αE2的保护作用在携带APOE4基因型的小鼠中最为明显.
  • 结合17αE2和口疫并没有产生附加治疗益处.

结论:

  • 提高寿命的干预措施显示出作为阿尔茨海默氏症治疗方法的巨大潜力.
  • 这些治疗方法即使在疾病过程中晚期启动,也可能是有效的.
  • 这些可翻译干预措施的进一步研究和改进对于AD治疗是有必要的.