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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

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此摘要是机器生成的。

脑位 (LC) 完整性与无症状阿尔茨海默病 (AD) 患者的粉样和病理有关. 这表明LC在早期AD病原体中起着关键作用,甚至在症状出现之前.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经病理学神经病理学
  • 放射学 放射学是一门学科.

背景情况:

  • 骨位 (LC) 是阿尔茨海默氏症 (AD) 中病理的早期部位,在临床症状之前.
  • 调查与粉样蛋白和沉积有关的LC完整性对于了解临床前AD至关重要.

研究的目的:

  • 为了确定是否位置coeruleus (LC) 完整性与体内皮质粉样蛋白和tau沉积在无症状,有风险的老年人.
  • 探索LC完整性和早期AD特征之间的关系.

主要方法:

  • 使用3TMRI和PET成像 (18F-NAV4694用于粉样蛋白,18F-flortaucipir用于) 在208名健康的老年人中,具有AD的家族病史.
  • 使用神经黑色素敏感脑干成像 (LCCNR) 和区域皮质粉样蛋白/沉积 (SUVR) 的量化LC完整性.
  • 采用了强大的线性混合效应模型和线性回归,对年龄,性别和教育进行校正,FDR对p值进行调整.

主要成果:

  • 在大多数地区,LC完整性和皮质粉样蛋白SUVR之间发现了负相关性.
  • 脊髓完整性显示在部和下部区域与皮质有关,特别是在左半球.
  • 这些关联在基线存在,而不是纵向存在,tau-LC关系是由全球粉样蛋白水平调节的.

结论:

  • 在无症状的个体中,有AD风险因素的局部 (Locus coeruleus,LC) 退化与粉样蛋白和蛋白病理增加有关.
  • 这些发现支持LC模型作为阿尔茨海默病早期病理生理变化的核心参与者.