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相关概念视频

Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Taylor W Schmitz1

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概括
此摘要是机器生成的。

这项研究使用人类和小鼠的触摸屏认知测试来了解阿尔茨海默病 (AD) 机制. 研究结果可能揭示了ApoE等遗传风险因素如何影响早期认知衰退.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学是一种遗传学.
  • 认知科学 认知科学

背景情况:

  • 认知测试的跨物种翻译对于阿尔茨海默病 (AD) 研究至关重要.
  • 鼠标模型提供了对受遗传和生物因素影响的认知衰退的机制性见解.
  • 触摸屏的认知任务使得人类和小鼠的一致测试,桥梁临床前和临床研究.

研究的目的:

  • 在AD小鼠模型和患AD风险的人类并行研究中整合同源的触摸屏认知测试.
  • 探索遗传因素 (粉样蛋白,,ApoE) 如何与执行职能中的年龄和性别相互作用,使用持续性能任务 (CPT).
  • 研究触摸屏认知测试在阐明AD风险机制和早期认知功能障碍方面的作用.

主要方法:

  • 利用西部大学和麦吉尔大学之间持续的合作.
  • 利用下一代AD小鼠模型与人性化的敲进基因.
  • 将基于触摸屏的选择性注意力探针Continuous Performance Task (CPT) 整合到纵向PREVENT-AD人类研究中.

主要成果:

  • 在PREVENT-AD研究中,包括425多名患有阿尔茨海默病风险的个体,已整合了CPT测试.
  • 从PREVENT-AD队列中从大约80名参与者获得了纵向CPT数据.
  • 具有人性化的ApoE基因型的小鼠模型正在用于研究执行功能.

结论:

  • 人和小鼠的基于触摸屏的认知测试可以阐明AD风险机制.
  • 在早期认知功能障碍中,PREVENT-AD和小鼠CPT数据可能会揭示ApoE基因型,年龄和性别之间的相互作用.
  • 与标准的神经心理测试相比,触摸屏测试可能对与AD相关的早期认知衰退具有更强的敏感性.