全免疫性炎症值与慢性病之间的关联:来自NHANES数据库的洞察力
Zihan Liu1, Haiyang Wang1, Zihao Zhang2
1Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu 241002, Anhui, China; Auhui Provincial Engineering Research Centre for Molecular Detection and Diagnostics, College of Life Sciences, Anhui Normal University, Wuhu 241002, Anhui, China.
Cytokine
|December 23, 2025
概括
全免疫-炎症值 (PIV) 显示了与慢性病 (CKD) 风险的J形联系. 升高的PIV与CKD患病率的增加有关,独立于其他因素.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物研究 生物标志物研究
背景情况:
- 全免疫-炎症值 (PIV) 是一个集成的免疫细胞生物标志物.
- 慢性病 (CKD) 是一种炎症性疾病.
- 在CKD中PIV的作用尚不清楚.
研究的目的:
- 调查PIV和CKD患病率之间的关联.
- 探索PIV和CKD之间的非线性关系.
- 评估PIV作为CKD风险的潜在生物标志物.
主要方法:
- 对39,156名NHANES参与者 (2011-2018) 的横截面分析.
- 权重多变量逻辑回归模型.
- 对于非线性关联的限制立方线 (RCS) 分析.
主要成果:
- 增加的PIV与增加的CKD患病率有显著的关联.
- 在PIV和CKD风险之间观察到J形关系.
- 关联在人口统计和临床子组中保持一致.
结论:
- 在PIV和CKD之间存在非线性,积极的关联.
- PIV可以作为CKD风险分层的补充生物标志物.
- 需要进一步的研究来探索PIV在炎中的作用.
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