头部和部状细胞癌中循环瘤DNA:文献综述
Léo Ventelou1, Angeline Ginzac2, Marie-Céleste Ferreira3
1Medical Oncology Department, Jean PERRIN Center, 63011 Clermont‑Ferrand, France.
Cancer treatment reviews
|December 23, 2025
概括
循环瘤DNA (ctDNA) 显示出对监测头癌 (HNC) 治疗反应的前景,特别是在与HPV相关的病例中. 需要进一步的标准化和大规模的研究来实现临床整合.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物研究 生物标志物研究
背景情况:
- 头癌 (HNCs) 往往是晚诊断的,导致预后不佳.
- 循环瘤DNA (ctDNA) 为HNC管理提供了一种最少的侵入性方法.
- ctDNA有助于早期检测,疾病监测和治疗向.
研究的目的:
- 在过去十年中,批判性地审查ctDNA在头癌中的临床应用.
- 综合HPV相关和非HPV相关的HNCs的证据.
- 评估目前关于ctDNA在HNC患者护理中的作用的证据.
主要方法:
- 使用PubMed和Cochrane图书馆进行了全面的文献审查.
- 关键词包括"循环瘤DNA"",头癌"",ctHPV-DNA"和"液体活检".
- 该审查分析了最初363篇文章中的92篇精选文章.
主要成果:
- ctDNA已被用于查,诊断,预后,治疗反应,复发检测和目标识别.
- 由于异质性,在研究中存在ctDNA性能的显著变化.
- 在HNC管理中的各种应用中,ctDNA的潜力显而易见.
结论:
- ctDNA显示了对治疗反应评估和治疗后监测的重大潜力,特别是在与HPV相关的HNC.
- 在前性试验中进行方法标准化和验证对于临床实施至关重要.
- 基于ctDNA的液体活检代表了HNC护理的有希望的进步.
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