系统性红斑狼中的代谢学:系统性审查和元分析
Susana Barrera-Hernández1, Claudia Mendoza-Pinto1, Pamela Munguía-Realpozo1
1Departamento de Reumatología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico; Unidad de Enfermedades Reumáticas y Autoinmunes Sistémicas, Unidad Médica de Alta Especialidad - Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico.
Seminars in arthritis and rheumatism
|December 23, 2025
概括
系统性红斑狼 (SLE) 患者表现出明显的代谢特征,具有较低的分支链和芳香氨基酸以及改变的脂质水平. 这些变化表明SLE中线粒体功能受损和单碳代谢.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 缺乏特定的生物标志物.
- 高通量代谢学可以识别SLE中的代谢干扰.
研究的目的:
- 通过系统性审查来确定与SLE相关的常见代谢物变化.
- 为了建立一个可复制的SLE.代谢签名.
主要方法:
- 在PubMed,科学网,Scopus和Cochrane图书馆进行系统的文献搜索,截至2024年11月.
- 包括人类观察性研究,将成年SLE患者与健康对照进行比较.
- 随机效应的元分析和异质性评估 (I2统计).
主要成果:
- 分析了46项研究 (2,238名SLE患者,1761名对照).
- 在SLE患者中显著降低异黄素,白素和氨酸;在SLE患者中较高的氨酸.
- 观察到油酸升高,酸降低,三碳酸中间体降低,甲胺酸增加.
结论:
- 一个可重复的SLE代谢特征包括较低的分支链/芳香氨基酸和改变的脂质配置文件.
- 这些代谢变化与线粒体能量受损相一致.
- 有证据表明,SLE患者的单碳流变化和线粒体应激.
关键词:
氨基酸是氨基酸的组成部分.生物标志物 生物标志物脂质 脂质 脂质 是一种代谢学 代谢学 代谢学系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.更多相关视频
相关概念视频
Microbial Interactions: Parasitism
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


