对精神疾病的遗传责任,并通过剖腹产分娩
Søren Dinesen Østergaard1, Maria Speed1, Alisha Silvia Mercedes Hall1
1Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
这是剖腹产产.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 产科 产科 产科 产科 产科
- 流行病学 流行病学
背景情况:
- 观察性研究将剖腹产与后代精神障碍联系起来.
- 因果关系仍然不确定,遗传因素可能造成混.
研究的目的:
- 调查遗传责任是否混了剖腹产和精神障碍之间的关联.
- 检查与分娩方式相关的主要精神疾病的多基因风险评分.
主要方法:
- 利用一个人口代表的队列,对精神分裂症,双相情感障碍,抑郁症,自闭症和多动症多基因风险评分 (PRS) 进行基因定型.
- 分析了PRS与剖腹产 (计划和急性) 的关联,使用了通用线性模型.
- 根据相关的共变量进行调整,以计算调整的赔率比率 (AOR).
主要成果:
- 在整体多基因风险得分和剖腹产之间没有发现任何关联.
- 在精神分裂症,双相情感障碍和抑郁症的PRS和计划剖腹产之间观察到积极的关联 (AORs从1.06到1.07).
- 在急性剖腹产方面没有发现显著的关联.
结论:
- 遗传责任可能会混计划剖腹产和后代精神障碍之间的观察到的关联.
- 未来的研究应该考虑遗传倾向,以避免高估因果关系.
- 这些发现强调了在围产期心理健康研究中考虑遗传因素的重要性.
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