含有抗氧化纳米酶的响应pH的植物化学水凝,用于协同ROS清理和向炎症性肠病治疗

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Yunong Shi¹, Miaosheng Tian¹, Shuo Shi²

¹Graduate school, Hebei University of Chinese Medicine, Shijijiazhuang, Hebei 050000, PR China; Anorectal Department, Hebei Provincial Traditional Chinese Medicine Hospital, Shijiazhuang, Hebei 050000, PR China; Anorectal Department, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050000, PR China.

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概括

一种新的水凝将天然抗炎剂与纳米酶活性相结合,用于治疗炎症性肠病 (IBD). 这种双作用疗法在临床前模型中有效降低了氧化应激和炎症.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
胃肠病学胃肠病学

背景情况:

炎症性肠病 (IBD) 由于涉及氧化应激和慢性炎症的复杂病理生理学, presents显著的治疗挑战.
目前的治疗方法往往在有效性和副作用方面扎,需要新的治疗策略.

研究的目的:

开发和评估一个多功能水凝系统 (CeO2@Rh-gel) 用于针对性和可控的治疗IBD治疗剂的输送.
为了研究综合成分的协同抗氧化和抗炎作用,以增强IBD治疗.

主要方法:

制造一种对pH值有反应的水凝,封装Rhein (抗炎剂) 和氧化纳米粒子 (CeO2NP),具有ROS清除纳米酶活性.
在体外评估抗氧化性质 (SOD和CAT模仿) 和抑制LPS刺激的巨细胞中的促炎细胞因子.
在DSS诱导的小鼠结肠炎模型中的体内评估,以评估治疗疗效和潜在机制.

主要成果:

CeO2@Rh-gel系统证明了pH响应的受控释放,保护胃中的有效载荷,并在炎症结肠中释放它们.
在体外研究表明,协同ROS清理和抑制炎症标志物.
在大肠炎模型中,口服药物显著减轻了疾病的严重程度,减轻了体重减轻,大肠长度正常化,改善了组织病理学,恢复了氧化还原平衡.

结论:

CeO2@Rh-gel水凝通过结合ROS清除,抗炎作用和可控输送,为精密IBD治疗提供了一个有前途的双功能策略.
这种方法有效地针对IBD复杂的病理生理学,解决氧化应激和慢性炎症.

关键词:

氧化纳米酶的氧化.IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD 具有PH反应的水凝.协同效应治疗是一种协同效应疗法.

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