在MASHAD队列研究中,P波持续时间与所有原因和心血管死亡率的关联
Hedieh Alimi1, Ali Tajik2, Mohsen Moohebati1
1Vascular and Endovascular Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of electrocardiology
|December 23, 2025
概括
在心电图上连续的P波持续时间预测了心血管和所有原因死亡率. 对于PWD,标准的120毫秒截止时间具有有限的预后价值,这表明需要对心血管风险分层进行精细评估.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 来自心电图 (ECG) 的P波指数表明心房导电.
- P波持续时间 (PWD) 与各种病理有关,但其与心血管死亡率的关联需要进一步调查.
研究的目的:
- 为了确定P波持续时间 (PWD) 与MASHAD队列研究人群中的心血管和全因死亡率之间的关联.
主要方法:
- 该研究分析了MASHAD队列中的8885名参与者,收集了人口统计和病史数据.
- 使用心电图来测量PWD,根据120毫秒的截止时间对参与者进行分类.
- 考克斯回归,重新分类指标 (NRI,IDI),卡普兰-梅尔图,ROC曲线和受限立方线 (RCS) 用于10年随访期间的死亡关联分析.
主要成果:
- 持续PWD在调整共变量后与更高的全因和心血管死亡率有显著的关联.
- 分类性PWD (≥120 ms vs. <120 ms) 没有显示出与心血管死亡率的显著关联.
- 将PWD添加到传统模型中并没有显著改善风险重新分类或歧视;然而,RCS表明连续PWD和全因死亡风险之间存在正线性相关性.
结论:
- 连续的P波持续时间是所有原因和心血管死亡率的重要预测因素.
- 对于PWD来说,传统的120毫秒的截止时间在这个队列中显示出有限的预后效用.
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