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免疫细胞衍生的细胞因子协同相互作用,驱动突纤维细胞的侵入性功能和代谢能力

Órla Tynan1, Alyssa Gilmore1, Aenea A I Brugman1

  • 1Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland.

Journal of autoimmunity
|December 23, 2025
PubMed
概括

干白素-1β (IL-1β) 和转化生长因子-β (TGF-β) 协同促进类风湿性关节炎纤维细胞样同胞细胞的功能. 使用塔基尼布阻断TAK1可降低类风湿性关节炎的炎症和突生长.

关键词:
纤维细胞样同胞细胞 (FLS)介质白素 (IL) - 1ββ 介质白素 (IL) - 1ββ 介质白素类风湿性关节炎 类风湿性关节炎 类风湿性关节炎转化生长因子 (TGF) -β-转化生长因子

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