全球性白血病减少输血的情况
Nicholas Tong1, Debra Masel2, Phuong-Lan Nguyen2
1Department of Pathology and Laboratory Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11550, United States.
概括
全方位白血病减少,从血液制品中去除白血细胞,减少输血反应和感染. 实施这一过程为患者带来了显著的益处,并且具有成本效益.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 免疫学 免疫学 免疫学
背景情况:
- 血红细胞减少可以从血液成分中去除白细胞.
- 已知它可以降低发烧性非溶血性输血反应,CMV感染,HLA合免疫和血小板折射性.
- 尽管有记录的好处,但FDA并没有强制要求普遍减少白血病.
研究的目的:
- 审查支持和反对普遍白血病减少的证据.
- 倡导在血液制品制造和输血中实施通用白血病减少.
主要方法:
- 观察性研究的审查.
- 对回顾性试验的分析.
- 随机对照试验的评估.
主要成果:
- 血红细胞减少在减少输血不良结果方面表现出有效性.
- 有证据支持从血液成分中去除白细胞的好处.
- 成本效益分析表明了财务可行性.
结论:
- 应该采用全方位的白血病减少来提高患者的安全性.
- 推实施全方位白血病减少,以改善患者的治疗结果.
- 采用普遍的白血病减少在经济上是合理的.
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