Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Changes of Physicochemical Indicators and Volatile Compounds in Grains and Liquors During the Sauce-Aroma <i>Baijiu</i> Brewing Process.

Foods (Basel, Switzerland)·2026
Same author

Functions of the prp operon in carbon source metabolism and acetic acid resistance in acetic acid bacteria: a case study in Acetobacter pasteurianus CGMCC 1.41.

BMC microbiology·2026
Same author

Multifunctional Peanut Shell-Derived Carbon Dots/Chitosan-Polyvinyl Alcohol Composite Films for Preservation of Fruits.

Journal of food science·2026
Same author

Can we refute a role for infections in Alzheimer's disease pathogenesis?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Microwave Pretreatment of Peanuts Modulates Oil Body Emulsion Stability: Mechanism and Application as a Source Modification Strategy for Efficient Demulsification.

Foods (Basel, Switzerland)·2026
Same author

Reconfiguring the Nonreducing Polyketide Synthase of <i>Monascus</i> Azaphilone Pigment Biosynthesis for Collaboration with A Highly Reducing Polyketide Synthase.

Journal of natural products·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Kanayo Satoh1, Ye Zhou1, Roger B Dodd2

  • 1University of Toronto, Toronto, ON, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

集群蛋白 (CLU) 在阿尔茨海默氏症 (AD) 大脑中结合CD33 (酸结合性免疫球蛋白类列蛋白3受体). 这种相互作用会损害微质细胞的Aβ吸收和斑块清除,这表明阿尔茨海默病的治疗标.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经免疫学 神经免疫学
  • 阿尔茨海默氏症疾病的发病因子
  • 微质功能 微质功能

背景情况:

  • 微质上与酸结合的免疫球蛋白类列丁3受体 (CD33) 调节与阿尔茨海默病 (AD) 相关的免疫反应.
  • 集群蛋白 (CLU) 和阿波利波蛋白E (ApoE) 涉及AD病原体,但它们作为CD33连接体的作用尚不清楚.
  • 研究CLU和ApoE与CD33的相互作用对于理解AD机制至关重要.

研究的目的:

  • 为了确定聚类蛋白 (CLU) 和/或阿波蛋白E (ApoE) 是否与CD33.3结合.
  • 检查CD33-CLU/ApoE相互作用对粉样β (Aβ) 摄取和斑块清除的功能后果.
  • 阐明CD33-CLU相互作用在AD病变发生中的作用.

主要方法:

  • 同免疫沉和定量生物层干涉计 (BLI) 评估了CD33与CLU和ApoE结合.
  • 分析了结合亲缘关系和CD33的Arg119残留物的作用.
  • 在现场近距离结合试验 (PLA) 和功能试验评估了相关细胞模型和人类大脑溶解物中的Aβ吸收和斑块清除.

主要成果:

  • 集群蛋白 (CLU),但不是ApoE,证明了与CD33的化依赖的高亲和度结合,需要完整的Arg119残留物和二度CD33.
  • 在AD大脑中,CD33和CLU在粉样蛋白斑块附近的微质上聚合.
  • 化CLU抑制了单细胞中的Aβ吸收,并降低了粉样斑块的清除,而非化CLU没有影响;CLU + Aβ寡合物增强了CD33 ITIM信号传递.

结论:

  • 集群蛋白 (CLU) 被确定为一种特定的CD33连接体,通过AD中CD33 ITIM信号调节微质功能.
  • 化CLU损害了Aβ吸收和粉样质斑块的清除,导致AD的微质功能障碍.
  • 准CD33-CLU轴为恢复微质平衡和增强AD中的粉样蛋白清除提供了潜在的治疗策略.