基础科学和病原发生学
Grace C George1, Sarah A Keller1, W Ryan Powell1
1Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
用区域贫困指数 (ADI) 衡量的弱势社区与脑血管疾病 (CVD) 神经病理病的几率增加有关. 这项研究强调了社区贫困对国家大脑捐赠者队列中大脑健康的影响.
科学领域:
- 神经病理学神经病理学
- 公共卫生 公共卫生
- 社会流行病学 社会流行病学
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 是复杂的,与社会经济因素有关.
- 结构上的不平等,例如生活在弱势社区 (根据区域贫困指数 - ADI进行索引),增加了ADRD风险.
- 脑血管疾病 (CVD) 是痴呆症中常见的共患病,但它与邻居剥夺的关系未得到充分研究.
研究的目的:
- 调查社区贫困 (ADI) 与脑血管疾病 (CVD) 神经病理学的存在之间的联系.
- 分析来自邻里研究中的国家大脑银行捐赠者样本的数据.
- 了解更高的社区贫困是否预测多元化的队列中的心血管疾病.
主要方法:
- 利用来自21个阿尔茨海默氏病研究中心 (ADRC) 的7,187名脑捐赠者参与者的数据.
- 将死亡时的捐赠者地址链接到国家ADI百分位数,分类为第三类.
- 评估CVD神经病理学 (心脏病发作,出血,微心脏病发作,白质稀缺) 使用NACC数据和后勤回归,根据性别,年龄和APOE状态进行调整.
主要成果:
- 大约25%的捐赠者居住在贫困地区,52%的捐赠者患有心血管疾病.
- 增加的ADI显著预测了心血管疾病神经病变的更高几率 (OR = 1.16,p < .001).
- 与中 (54.6%) 和最高 (54.7%) 的第三层相比,贫困最低的第三层的捐赠者具有显著较少的心血管疾病 (48%).
结论:
- 在国家大脑捐赠者队列中,更高的邻居贫困与心血管疾病神经病理病的几率增加有关.
- 研究结果表明,社会经济劣势和脑血管病理之间存在联系.
- 需要进一步的研究来阐明驱动这些协会的机制.
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