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相关概念视频

Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Urinary Tract Infection II: Pathophysiology01:25

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Olga Minaeva1, Kevin P Kotredes2, Juliet A Moncaster1

  • 1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

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概括
此摘要是机器生成的。

在长期暴露后,,和等环境毒素在小鼠的大脑和血液中积累. 这项研究证明了它们在大脑区域的检测和映射,突出显示了毒素暴露与阿尔茨海默病风险之间的联系.

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科学领域:

  • 神经科学是一个神经科学.
  • 环境健康 环境健康
  • 毒理学 毒理学 毒理学

背景情况:

  • 阿尔茨海默病 (AD) 和相关的痴呆症 (ADRD) 受年龄,遗传和环境暴露的影响.
  • 包括 (Pb), (Cd) 和 (As) 在内的环境有毒物质对公众健康构成重大风险,不成比例地影响弱势群体.
  • 这项研究探讨了这些神经毒剂改变AD相关基因表达并增强AD病理生物学的假设.

研究的目的:

  • 研究长期暴露后小鼠大脑中 (Pb), (Cd) 和 (As) 的积累和区域分布.
  • 为了利用激光剥离感应合等离子体质谱 (LA-ICP-MS) 成像用于多元元素大脑映射和超微元素量化.
  • 建立环境毒素暴露和潜在的阿尔茨海默氏症病理生物学之间的联系.

主要方法:

  • 模型AD小鼠在饮用水中暴露于Pb,Cd或As30天.
  • 通过诱导合血质谱法 (ICP-MS) 分析大脑和血液样本以进行元素定量.
  • LA-ICP-MS成像用于精确的解剖定位和绘制脑组织中神经毒剂积累的地图.

主要成果:

  • 在30天暴露在流行病学相关水平后,在小鼠大脑和血液中观察到Pb,Cd和As的强烈吸收.
  • 在A,Cd和Pb的大脑和血液水平之间发现了强烈的相关性.
  • LA-ICP-MS测绘显示,神经毒剂在不同的大脑区域 (包括海马和皮质) 积累了非均的,元素特异性的神经毒剂.

结论:

  • 暴露在Pb,Cd或As中的AD模型小鼠会在血液和大脑中积累这些神经毒剂.
  • ICP-MS溶液分析和LA-ICP-MS成像有效地检测,图像和量化神经毒素积累.
  • 这些发现支持环境毒素在AD病理生物学中的潜在作用,需要进一步调查.