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甲酸盐毒性的表观遗传和表谱图景:对人类健康和疾病的影响

Ziqing Ye¹, Maimaiti Mayila², Na Bu³

¹Department of Immunology and Institute of Basic Medical Sciences, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, 830011, China; School of Pharmacological Sciences, Xinjiang Medical University, Urumqi, 830011, China.

Environmental pollution (Barking, Essex : 1987)

|December 23, 2025

概括

酸盐 (PAE) 通过改变表观遗传和表观转录机制来破坏人类健康. 本综述详细介绍了PAE暴露如何影响DNA甲基化,基因素修饰和RNA调节,从而导致各种疾病.

科学领域:

环境健康环境健康
分子生物学分子生物学
毒理学毒理学毒理学

背景情况:

酸盐 (PAE) 是无处不在的内分泌干扰化学物质,具有广泛的工业用途.
越来越多的证据将PAE暴露与不利的人类健康结果联系起来.
表观遗传和表观转录机制越来越被认为是PAE毒性的关键媒介.

研究的目的:

综合当前关于PAE如何破坏表观遗传和表观转录体调节层的知识.
将这些干扰与特定疾病联系起来,包括牛皮,糖尿病,动脉样硬化,生殖障碍和癌症.
讨论表观遗传/表观转录体标志物用于诊断和治疗的潜力.

主要方法:

对PAE毒性和表观遗传/表观转录学变化的现有文献的综述.
对研究PAE诱导的DNA甲基化变化,基因素修饰,RNA修饰和非编码RNA表达的研究进行分析.
整合发现,以建立分子机制和疾病发病机制之间的联系.

主要成果:

PAE会诱导全球和基因特异性DNA甲基化模式的改变.
经受PAE暴露会通过基因素乙化和甲基化导致染色质重塑.
非编码RNAs (miRNAs, lncRNAs) 的异常表达和动态RNA修饰被观察到对PAE的反应.

结论:

PAE对表观遗传和表体转录层的调节失调有助于各种疾病的发展.
表观遗传和表观转录体标记作为PAE相关疾病的诊断工具和治疗点具有前途.
需要进一步的跨学科研究,以了解长期影响,并制定缓解策略.

关键词:

负面的健康影响.通过DNA甲基化.基因组胺基因的修改非编码RNA (ncRNA) 是一种非编码RNA.病原发生和发病的过程.酸盐 (PAE) 是一种酸盐.塑料污染问题塑料污染问题在RNA m6A修改的过程中.

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