吸入三重疗法的相对粒子大小和分布
Brian Lipworth1, Enrico Zambelli2, Ruben Agazzi2
1Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, UK.
概括
贝克罗梅他松二 propionate/formoterol fumarate/glycopyrronium (BDP/FF/G) 提供较小的颗粒,增强喘和COPD患者的小气道透. 这种三重组合疗法显示出改善疾病控制的更大潜力.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 小呼吸道功能障碍在喘和COPD中很普遍,影响疾病控制和患者的健康.
- 有效地将吸入药物输送到小气道对于管理这些疾病至关重要.
研究的目的:
- 为了比较三种三重组合吸入器的空气动力学颗粒大小分布.
- 评估贝克罗梅他松二 propionate/formoterol fumarate/glycopyrronium (BDP/FF/G),布德索尼德/formoterol fumarate/glycopyrronium (BUD/FF/G) 和流 furoate/vilanterol/umeclidinium (FLU/VI/UMEC) 进入小气道的潜力.
主要方法:
- 用下一代冲击因子 (NGI) 分析来评估颗粒大小分布.
- 关键参数包括质量中介气动直径 (MMAD) 和超细粒子分数 (eFPF;<2μm).
- 用高性能液态染色学 (HPLC) 量化了组件质量.
主要成果:
- 与BUD/FF/G (3.02-3.36微米) 和FLU/VI/UMEC (1.96-4.13微米) 相比,BDP/FF/G表现出较低的MMAD (1.1微米).
- 比BUD/FF/G (10.5%-16.2%) 和FLU/VI/UMEC (6.8%-27.7%) 更高的BDP/FF/G显示了更高的平均eFPF (39.0%-39.9%).
- 在BDP/FF/G中,贝克洛梅他成分与布德索尼德和流动松成分相比,显示出明显更高的eFPF.
结论:
- 与BUD/FF/G和FLU/VI/UMEC相比,BDP/FF/G始终产生较小的颗粒.
- 较高的超细颗粒分数表明BDP/FF/G具有更大的潜力来准小气道.
- 这种改善的交付可能会导致喘和COPD患者的治疗结果更好.
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