Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites.

Nature communications·2026
Same author

Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance.

Current opinion in cell biology·2024
Same author

VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons.

The Journal of cell biology·2024
Same author

Super-resolution microscopy: Insights into mitochondria-lysosome crosstalk in health and disease.

The Journal of cell biology·2023
Same author

Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons.

Neuron·2023

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Kevin R Shen1, George C Shum1, Abby C Woods1

  • 1Northwestern University, Chicago, IL, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默病涉及粉样β (Aβ) 和病理. 这项研究揭示了Aβ42如何与ACAT1相互作用,改变胆固醇,ER结构和动力学,揭示了一个新的AD途径.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 生物化学 生物化学

背景情况:

  • 阿尔茨海默氏病 (AD) 与β-粉样蛋白 (Aβ) 和tau病理有关,但它们的相互作用和胆固醇静态阻断的作用尚不清楚.
  • 胆固醇平衡在内 плазма网膜 (ER) 中受到调节,涉及ACAT1酶和ER-微管接触对记忆至关重要.
  • 在阿尔茨海默病中,ACAT1,Aβ,ER胆固醇,ER结构和tau动态之间的功能联系仍未得到研究.

研究的目的:

  • 在阿尔茨海默病中发现一种连接胆固醇周转,Aβ功能和陶聚合的新型机制性途径.
  • 研究ER胆固醇在调节ER超结构,动态和ER微管接触点中的作用.
  • 确定Aβ42和Aβ40如何与ACAT1相互作用,并影响下游tau病理.

主要方法:

  • 使用超高分辨率的实时格子SIM2显微镜可视化ER动态和ER微管接触点.
  • 研究了Aβ生成和特定Aβ42/Aβ40比率对ER胆固醇循环和ER球形成的影响.
  • 进行了Aβ与ACAT1相互作用的结构多重模拟,并研究了STIM1-EB介导的连接.

主要成果:

  • 累积ER胆固醇诱导了新的ER球体形成,这也是由Aβ生成抑制引发的.
  • Aβ42,但不是Aβ40,在结构上与ACAT1相互作用,促进胆固醇循环,减少ER球形成.
  • ER胆固醇的积累导致了ER微管接触的解,导致tau解离和寡合化.

结论:

  • 提供了通过胆固醇介导的ER动态来将Aβ功能与tau动态联系起来的统一机制的证据.
  • 确定了一种涉及ACAT1和ER胆固醇周转在阿尔茨海默氏症病原发生过程中的新型细胞通路.
  • 突出了ER胆固醇在调节ER结构和微管相关的病理中的关键作用.