Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice.

Biochemistry and biophysics reports·2026
Same author

Ultraprocessed Foods and the Aging Brain: State of the Science.

Annual review of nutrition·2026
Same author

The landscape of dementia research, diagnosis, treatment, and care in Latin America.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Physical exercise protects against Toxoplasma gondii infection-induced muscle atrophy and microvascular rarefaction.

Communications biology·2026
Same author

The momentum for dementia research in Brazil.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

mRNA Translation and Proteasomal Degradation in Health and Neurological Disease.

Physiology (Bethesda, Md.)·2026

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Beatriz Wagner1, Mariana Chauvet1, Sergio T Ferreira2

  • 1Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

富含脱多不和脂肪酸 (D-PUFA) 的饮食保护了小鼠免受脂多糖 (LPS) 诱导的神经炎症和记忆缺陷的影响. 这表明D-PUFA饮食可能是缓解认知衰退的有希望的营养策略.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 营养科学 营养科学
  • 免疫学 免疫学 免疫学

背景情况:

  • 神经炎症,氧化应激和脂质过氧化与阿尔茨海默氏症等神经退行性疾病有关,导致认知能力下降.
  • 脱多不和脂肪酸 (D-PUFA) 促进抗炎途径,与前列腺素途径形成鲜明对比.
  • 受到D-PUFA影响的Lipoxin A4具有神经保护作用,并且在痴呆患者中降低.

研究的目的:

  • 研究D-PUFA丰富的饮食对脂聚糖 (LPS) 诱导的神经炎症的神经保护潜力.
  • 评估D-PUFA饮食对神经炎症动物模型认知功能的影响.

主要方法:

  • 小鼠在两个月内被食D-PUFA丰富的饮食或控制 (H-PUFA) 饮食.
  • 神经炎症是通过腹膜内脂聚糖 (LPS) 注射诱导的.
  • 使用新型对象识别 (NOR),移位对象识别 (DOR) 和开放领域任务来评估认知功能.

主要成果:

  • 在NOR和DOR测试中,食对照饮食并接受LPS治疗的小鼠表现出记忆缺陷.
  • 被养D-PUFA丰富饮食并接受LPS治疗的小鼠没有表现出记忆障碍.
  • 两组之间没有观察到体重增加或饮食消费的显著差异.

结论:

  • 富含D-PUFA的饮食显示出对LPS诱导的神经炎症和相关认知缺陷的神经保护作用.
  • 这些发现表明,D-PUFA饮食代表了减轻神经炎症和认知衰退的潜在营养干预.