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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Nazaret Gamez1, Abdulmunaim M Eid1, Belen Pascual1

  • 1Houston Methodist Research Institute, Houston, TX, USA.

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概括
此摘要是机器生成的。

前性痴呆症 (FTD) 患者表现出调控性T细胞 (Treg) 功能受损和炎症增加,特别是涉及CXCL10/CXCR3通路. 准这种途径可能会减少神经炎症和T细胞在大脑中的透.

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科学领域:

  • 神经免疫学 神经免疫学
  • 神经退行发生神经退行.
  • 前性痴呆症 (FTD) 是一种前性痴呆.

背景情况:

  • 炎症在神经退行中起作用,但其外周免疫系统在FTD中的作用尚不清楚.
  • 这项研究研究了调节性T细胞 (Tregs),单细胞和血炎症标记在非流动变体初级渐进性失言症 (nfvPPA) 中,这是FTD亚型.

研究的目的:

  • 评估nfvPPA患者的Treg抑制功能.
  • 分析 nfvPPA 中外围单细胞的炎症概况.
  • 测量 nfvPPA 中的血炎症标志物.

主要方法:

  • 通过增殖试验评估Treg抑制功能.
  • 使用纳米链和qRT-PCR分析了单细胞基因表达.
  • 用Olink® Target 48面板测量了血细胞因子.
  • 利用CyTOF用于PBMC免疫特征和信号通路分析.

主要成果:

  • nfvPPA患者的Treg抑制功能降低.
  • nfvPPA单细胞显示出促炎性基因表达的增加 (C1q,NLRP3,PRG3,CXCL10).
  • 血CXCL10升高,并确定了NFvPPA中的CXCL10/CXCR3通路激活.
  • 单细胞上的CXCL10和T细胞上的CXCR3;CXCL10促进T细胞炎症,被AMG487.7阻止.

结论:

  • nfvPPA与Treg功能受损和全身CXCL10/CXCR3通路激活有关.
  • 这一途径可能有助于T细胞向大脑定位.
  • 治疗策略可能包括恢复Treg功能和向CXCL10/CXCR3,以减少神经炎症和T细胞透.