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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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基础科学和病原发生学

Allison C Engstrom1, Arunima Kapoor1, Shubir Dutt2

  • 1University of California, Irvine, Irvine, CA, USA.

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概括
此摘要是机器生成的。

与年轻人相比,认知健康的老年人表现出明显减少的自发脑血管反应 (CVR). 这种CVR的下降可能是认知障碍之前的早期脑血管变化的信号.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 血管生物学 血管生物学

背景情况:

  • 脑血管反应 (CVR) 对于调节大脑血液流动至关重要.
  • 降低CVR可能表明血管功能障碍和认知障碍风险.
  • 了解与年龄相关的CVR变化至关重要,但先前的发现是混合的,休息的CVR研究不足.

研究的目的:

  • 为了比较健康的老年人和年轻人之间的休息时自发性脑血管反应 (CVR).
  • 调查全脑和区域心脏回路功能的与年龄相关的差异.

主要方法:

  • 招募健康的老年人 (n=129,平均年龄70岁) 和年轻人 (n=24,平均年龄22岁).
  • 使用伪连续动脉旋转标记MRI和图来测量脑输液和静止状态的etCO2.
  • 使用ANCOVA和基于voxel的形态测量 (VBM) 进行全脑和区域自发性CVR的比较.

主要成果:

  • 老年人与年轻人相比,全脑自发性CVR显著减少 (p < 0.000000000057).
  • 在大多数老年人的大脑区域,特别是中间叶,观察到减少自发的CVR.
  • 基于voxel的形态测量确定了区域集群,在老年人中CVR显著较低.

结论:

  • 与年轻的成年人相比,健康的老年人休息时自发心血管回转率降低.
  • 这些发现表明,脑血管功能变化可能发生在早期,可能在认知能力下降之前.
  • 自发性CVR可以作为与年龄相关的认知衰退的生物标志物,这需要进一步的年龄范围调查.