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评估DAPSA和DAPSA28在牛皮关节炎中的内部结构有效性:使用确认因素分析和额外的心理测试进行的一项欧洲观察研究

Jacob Brauner Jørgensen^1,2, Karl Bang Christensen³, Brigitte Michelsen^1,4,5

¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.

|December 23, 2025

概括

牛皮关节炎的疾病活动指数 (DAPSA) 和DAPSA28显示了牛皮关节炎疾病活动的可接受的内部一致性. 然而,关于模型合适性和差异性项目功能的混合结果表明需要进一步调查.

科学领域:

风湿病学和免疫学
临床评估和测量临床评估和测量

背景情况:

牛皮关节炎 (PsA) 需要可靠的工具来测量疾病活动.
为此目的,使用了银病关节炎的疾病活动指数 (DAPSA) 和其修改版DAPSA28.

研究的目的:

为了评估DAPSA和DAPSA28在大量牛皮关节炎队列中的心理测量特性.
评估这些疾病活动指标的内部结构有效性和内部一致性可靠性.

主要方法:

来自欧洲脊椎关节炎 (EuroSpA) 研究合作网络的1865名牛皮关节炎患者的数据分析.
心理测量评估包括确认因素分析 (CFA),结构方程建模 (SEM) 和Cronbach的alpha (CA) 以确保内部一致性.
差异性项目功能 (DIF) 评估了与性别和国家相关的潜在偏见.

主要成果:

一维CFA模型在基线时显示可接受的模型适合性,但在6个月的随访后不适合.
结合基线和后续数据的SEM分析没有产生可接受的模型匹配.
克伦巴赫的α表示了DAPSA (0.65) 和DAPSA28 (0.63) 的可接受的内部一致性可靠性.
对于性别和国家来说,检测到不同的项目功能,这表明了潜在的测量偏差.

结论:

虽然DAPSA和DAPSA28表现出可接受的内部一致性,但模型匹配和DIF存在的混合结果需要谨慎.
在国家层面和性别和国家的DIF不合适的证据表明潜在的限制.
建议对这些和其他牛皮关节炎疾病活性措施进行进一步的研究,以获得强大的临床应用.

关键词:

关节炎,牛皮,牛皮.流行病学流行病学结果评估,医疗保健

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