在患有系统性红血性狼的患者中,随着时间的推移,个体内认知功能的过程
Oshrat E Tayer-Shifman1,2, Jiandong Su3, Kathleen Bingham4
1School of Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
RMD open
|December 23, 2025
概括
认知障碍 (CI) 影响近一半的系统性红斑狼 (SLE) 患者超过一年,大多数病例稳定. 种族和疾病严重程度等因素会影响SLE持续性CI.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 精神病学是一个精神病学.
背景情况:
- 认知障碍 (CI) 是神经精神系统性红斑狼 (SLE) 的常见表现.
- 了解SLE中CI的纵向过程对于患者管理至关重要.
- 这项研究调查了SLE患者1年的CI轨迹.
研究的目的:
- 描述系统性红斑狼 (SLE) 患者认知障碍 (CI) 的1年过程.
- 在SLE患者中,在12个月的时间内确定与CI持久性相关的因素.
主要方法:
- 175名成年SLE患者在基线,6个月和12个月使用美国风湿病学学院神经心理学电池进行了评估.
- 认知障碍 (CI) 根据标准化的z-score被分类为持久性,波动性或从未CI.
- 收集了社会人口统计,临床,实验室和药物数据,以确定相关因素.
主要成果:
- 在1年内,46%的SLE患者出现了CI,其中17%是持续的,29%是波动的.
- 与波动性CI相比,持久性CI与更严重的损伤有关.
- 与持续性CI相关的因素包括黑人种族,诊断时的年龄较大,离婚/分居状态和更高的疾病损伤.
结论:
- 在SLE患者中,认知障碍呈现出可变的过程,大多数患者在一年内表现出稳定的模式.
- 社会人口统计学因素和并发症在SLE中CI的持续性方面发挥着重要作用.
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