早期生命休息状态网络功能连接性和新生儿脑病变后的长期神经发育结果
Daphne Kamino1, Anwar S Shatil1, Jessy Parokaran Varghese1
1From the Neurosciences and Mental Health Program (D.K., A.S.S., J.P.V., E.W., B.T.D., V.C., E.W.Y.T.), SickKids Research Institute, Toronto, Ontario, Canada.
AJNR. American journal of neuroradiology
|December 23, 2025
概括
患有脑病变的新生儿早期脑部扫描显示,特定的功能连接模式与以后的发育有关. 在生命的第一个星期休息状态网络功能连接 (FC) 可以预测36个月的神经发育结果.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 医疗成像医学成像
背景情况:
- 新生儿脑病变 (NE) 构成长期神经发育障碍的重大风险.
- 早期评估NE幸存者的大脑功能对于识别那些处于更高风险的人至关重要.
- 休息状态网络 (RSN) 功能连接 (FC) 为早期大脑功能提供了潜在的窗口.
研究的目的:
- 在NE幸存者中调查RSN FC在生命的第一周和神经发育结果在18个月和36个月之间的关系.
- 为了确定早期的功能性大脑连接是否可以预测长期的神经发育轨迹.
- 探索特定的RSN及其与认知和行为结果的关联.
主要方法:
- 一个前性队列研究治疗性低温治疗新生儿与NE.
- 休息状态功能性MRI (rs-fMRI) 在生命的第一个星期进行.
- 基于种子的相关性分析被用于评估6个RSN内的和6个RSN之间的FC,并在18个月和36个月后进行随访.
主要成果:
- 在72名新生儿中,52人有足够的rs-fMRI数据;45人完成了36个月的随访.
- 在多次比较校正后,RSN内FC强度与18个月或36个月的结果没有相关性.
- 特定的Somatomotor RSN连接 (运动区域) 与语言分数相关,以及 Ventral Attention RSN连接 (状状结) 与36个月的外部化行为分数相关.
结论:
- 生后第一周的RSN FC与NE幸存者的36个月神经发育结果有关.
- 早期的rs-fMRI可以为预测长期神经发育轨迹提供宝贵的临床见解.
- 这种非侵入性成像技术可能有助于早期风险分层和干预计划.
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