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与口腔潜在恶性疾病和口腔癌有关的自我报告的种族和种族
Adriana Mendonca da Silva1, Polyanna Oliveira2, Mariana Bezamat Chappel3
1Arizona School of Dentistry & Oral Science, A.T. Still University, Mesa, AZ, USA.
Oral surgery, oral medicine, oral pathology and oral radiology
|December 23, 2025
概括
自我报告的种族和种族与口腔潜在恶性疾病和口腔癌有关. 非洲裔美国人表现出明显更高的风险,特定基因变异进一步增加了这种风险.
科学领域:
- 口腔健康研究 口腔健康研究
- 遗传学和疾病风险
- 在健康方面存在差异.
背景情况:
- 口腔潜在恶性疾病和口腔癌对健康构成重大关注.
- 了解人口统计学关联对于有针对性的预防和早期检测至关重要.
- 遗传和环境因素可能会影响不同人群的疾病易感性.
研究的目的:
- 检查自我报告的种族和族裔与口腔潜在恶性疾病和口腔癌的发生之间的关系.
- 探索潜在的遗传影响,特别是单核酸变异,对这些口腔健康结果.
- 在种族/种族和口腔疾病风险的背景下考虑环境因素.
主要方法:
- 一项涉及牙科诊所792名参与者的病例控制研究.
- 病例包括患有口腔潜在恶性疾病或口腔状细胞癌的受试者;对照组根据性别和年龄进行匹配.
- 统计分析包括千二测试,逻辑回归和单核酸变异的检查 (rs9879992-GSK3B).
主要成果:
- 自报为非洲裔美国人的人患口腔潜在恶性疾病/口腔癌的风险增加了78% (OR,1.78;P = .002).
- rs9879992-GSK3B的小等位基因G与非裔美国人的风险增加有关 (OR,1.85;P = .002).
结论:
- 自我报告的种族和种族与口腔潜在恶性疾病和口腔癌有显著的关联.
- 遗传因素,如rs9879992-GSK3B变异,可能会在特定种族群体中增加风险.
- 建议利用祖先信息标记的进一步研究来验证这些发现.
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