基础科学和病原发生学
Rifaldy Fajar1, Sahnaz V Putri2, Prihantini Prihantini3
1Yogyakarta State University, Sleman, Special Region of Yogyakarta, Indonesia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
少数民族的压力加速表观遗传衰老超过6年,增加阿尔茨海默病的风险. 社会支持可以缓解这个衰老过程,突出了包容性研究的必要性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 计算生物学 计算生物学
背景情况:
- 少数民族的压力可能会加速生物衰老和恶化神经退行,特别是在接受性别肯定激素治疗 (GAHT) 的跨性别个体中.
- 少数民族压力,表观遗传衰老和阿尔茨海默病 (AD) 进展之间的联系仍然未得到充分探索.
- 本研究使用人工智能驱动的方法来调查这些关系.
研究的目的:
- 探索少数民族压力对表观遗传衰老和阿尔茨海默病 (AD) 进展的影响.
- 开发和验证一个人工智能驱动的框架来分析这些复杂的相互作用.
- 识别潜在的保护因素,如社会支持.
主要方法:
- 综合公开可用的DNA甲基化,神经成像和社会人口统计数据.
- 采用合成数据增强来建模GAHT暴露和少数群体压力.
- 使用基于变压器的变化自编码器进行数据协调和组合随机森林/时间图卷积网络 (T-GCN) 进行分析.
主要成果:
- T-GCN模型显示了AD进展的强有力的预测性能 (AUC:0.86).
- 少数民族压力与平均表观遗传年龄加速6.2年有关,FKBP5和NR3C1基因发生显著变化.
- 加快表观遗传衰老与海马体积减少和粉样β沉积增加相关;社会支持减少了21%的表观遗传衰老.
结论:
- 一个新的AI框架被开发出来,以了解少数群体的压力诱导的表观遗传衰老及其对AD的影响.
- 使用先进的计算技术来解决包容性AD研究中的差距.
- 这些发现有助于开发针对AD的精确医疗保健策略.
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