Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.

Cellular and molecular neurobiology·2026
Same author

EEG-motor correlation as early Alzheimer's disease index in herpes simplex virus type-1-infected mice.

Brain communications·2026
Same author

Memantine prevents acute stress-induced memory deficits by reversing sex-dependent pathophysiological glutamatergic alterations in the dorsal hippocampus.

British journal of pharmacology·2026
Same author

Neuroinflammatory responses and synaptic impairment in a Herpes simplex virus type 1 model of sporadic Alzheimer's disease.

Neural regeneration research·2026
Same author

Intranasal administration of neural stem cell-derived extracellular vesicles prevents cognitive decline in both male and female 3×Tg-AD mice by dampening neuroinflammation and epigenetically regulating amyloid β metabolism.

Alzheimer's research & therapy·2026
Same author

AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain.

Scientific reports·2026

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Claudio Grassi1,2, Francesca Natale2,3, Matteo Spinelli3,4

  • 1Università Cattolica del Sacro Cuore, Rome, Rome, Italy.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

异常的S-palmitoylation与阿尔茨海默病 (AD) 的认知衰退有关. 抑制zDHHC酶和S-palmitoylation为AD提供了一个有希望的治疗策略.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 蛋白质的翻译后修改,包括S-palmitoylation,对于突触功能至关重要.
  • 这些修饰的破坏与神经退行性疾病,如阿尔茨海默氏症 (AD) 有关.
  • 含指DHHC域 (zDHHC) 的S-转移酶催化S-棕结合,影响突触可塑性和粉样蛋白β (Aβ) 代谢.

研究的目的:

  • 调查zDHHC酶和S-palmitoylation在AD病变发生中的作用.
  • 在AD模型中评估调节S-palmitoylation的治疗潜力.

主要方法:

  • 在AD小鼠模型和人类AD患者海马体中分析zDHHC表达和S-palmitoylation.
  • 在体内抑制zDHHC使用2-棕酸盐 (2-BP) 或反感性寡核酸.
  • 通过lentiviral载体和短发针RNA进行海马的zDHHC沉默.
  • 棕基蛋白质组分析以确定zDHHC7的点.

主要成果:

  • 在AD模型和患者中观察到增加的zDHHC7表达和突触蛋白S-palmitoylation.
  • 在AD小鼠中,2-BP治疗和zDHHC7沉默改善了突触可塑性,减少了Aβ沉积,并增强了认知功能.
  • 在AD患者中,S-palmitoylation水平与认知表现相反相关.
  • 确定涉及神经退行症的潜在zDHHC7目标.

结论:

  • 异常的S-palmitoylation是AD相关的突触功能障碍和认知障碍的一个关键因素.
  • 准zDHHC酶为缓解AD的认知衰退提供了一个新的治疗途径.