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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Domenica Donatella Li Puma1,2, Roberto Piacentini2,3, Giammarco Boni3

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疹简单病毒1型 (HSV-1) 在小鼠中的重新激活诱导阿尔茨海默氏症.

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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学

背景情况:

  • 疹简单病毒1型 (HSV-1) 在小鼠大脑中的重新激活会触发类似阿尔茨海默病 (AD) 的表型.
  • 这种表型包括突触和记忆缺陷,高素-1β (IL-1β),以及粉样蛋白-β (Aβ) 和化陶 (pTau) 的积累.
  • 作为IL-1受体阻塞剂的阿纳金拉在两次热应激 (2TS) 事件后逆转了神经退行标志物.

研究的目的:

  • 研究IL-1β,Aβ和Tau在驱动HSV-1感染小鼠的突触功能障碍中的相互作用.
  • 为了阐明IL-1β介导的神经炎症在早期AD中的作用.
  • 了解Aβ和pTau如何促进IL-1β积累和突触功能障碍.

主要方法:

  • 在野生型 (WT),Aβ缺陷 (APP-/-) 和pTau缺陷 (Tau-/-) 的小鼠中,HSV-1感染和2TS诱导的病毒活性.
  • 进行了分子,电生理学 (长期增强 - LTP) 和行为 (新物体识别) 分析.
  • 测量IL-1βmRNA水平和微质激活 (CD86表达) 的测量.

主要成果:

  • 与WT小鼠相比,感染HSV-1的Tau-/-和APP-/-小鼠的IL-1β水平较低,微质激活减少.
  • 转基因小鼠比WT小鼠表现出较轻微的突触缺陷 (LTP) 和记忆障碍.
  • 较低的IL-1β水平在APP-/-和Tau-/-小鼠与减少的突触功能障碍相关.

结论:

  • 在这种AD小鼠模型中,IL-1β介导的神经炎症对于驱动突触功能障碍至关重要.
  • Aβ和pTau有助于IL-1β的积累,在AD中创造了一个突触功能障碍的循环.
  • 向IL-1β可能为早期的AD提供治疗策略.