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母亲急性SARS-CoV-2感染会损害植入前胚胎发育,并重新编程早期后代的造血系统

Meiling Zhang¹, Di Liu², Songmao Li³

¹International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhml1119@sina.com.

|December 23, 2025

概括

母亲的SARS-CoV-2感染会损害胚胎发育,并改变后代.

科学领域:

生殖生物学生殖生物学
发展生物学发展生物学
免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

急性SARS-CoV-2感染对辅助生殖技术的结果构成风险.
关联母亲感染与胚胎发育受损和后代健康的分子机制尚不清楚.

研究的目的:

研究母体SARS-CoV-2感染对植入前胚胎发育的影响.
评估对早期后代造血系统的长期影响.

主要方法:

胚胎和带血 (UCB) 细胞的单细胞RNA测序 (scRNA-seq).
大量RNA-seq和DNA甲基化对胎盘组织的分析.
综合多组织分析.

主要成果:

孕产妇感染导致胚芽细胞发育迟缓,基因表达和能量代谢发生变化 (氧化酸化抑制,糖解增强).
在植入前胚胎中观察到异常的DNA甲基化模式.
新生儿显示炎症性细胞因子增加,单细胞丰富,和骨髓偏向的造血干细胞和原始细胞 (HSPCs) 与减少的氧化酸化.

结论:

母亲的SARS-CoV-2感染会破坏植入前胚胎的发育.
长期影响包括能量代谢失调,表观遗传变化,以及后代造血系统中偏斜的免疫反应.
这些变化可能会影响长期的免疫功能.

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