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Updated: Jan 8, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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光酶催化使得抗选择性基因的芳香性螺旋循环化成为可能

Changtong Zhu1, Yan Zhang2, Zhiwei Deng1

  • 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, PR China.

Nature communications
|December 23, 2025
PubMed
概括

这项研究引入了一种新的光酶学方法,用于使用工程酶和可见光制造复杂的性螺旋循环. 这种绿色化学方法可以有效地合成有价值的制药构建块.

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Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
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