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Updated: Jan 8, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
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反NMDAR1抗体和IL-17信号通路形成了NMDAR脑炎的形状

Zhenhong Xu1,2, Hongye Yan1,2, Bo Wang1,2

  • 1The First Affiliated Hospital, Multi-Omics Research Center for Brain Disorders and Department of Neurology, Hengyang Medical School, University of South China, 421001, Hengyang, HN, China.

Molecular psychiatry
|December 23, 2025
PubMed
概括

抗N-甲基-D-酸盐受体脑炎 (NMDARE) 涉及自身抗体和大脑炎症. 这项研究发现,患者的脑脊液中介质素-17 (IL-17) 信号传递会导致神经元过激,这表明IL-17阻断是潜在的NMDARE疗法.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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