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使用ICG-p28进行手术内成像来改善DCIS切除

Sunam Mander¹, Masahide Goto¹, Konstantin Christov¹

¹Division of Surgical Oncology, Department of Surgery, University of Illinois College of Medicine, Chicago, IL, 60612, USA.

Scientific reports

|December 23, 2025

概括

一种新的近红外光成像探测器ICG-p28有效地确定了局部导管癌 (DCIS) 鼠标模型中的瘤边缘. 这种方法显示出降低图像引导乳腺癌手术中再切割和复发率的前景.

科学领域:

在瘤学瘤学.
医疗成像医学成像
手术创新在外科创新.

背景情况:

在位管道癌 (DCIS) 是乳腺癌的最早形式,通常用乳腺保护手术 (BCS) 治疗.
在BCS期间实现完全的瘤切除与明确的边缘对于预防局部复发至关重要,但正边缘率仍然很高 (DCIS的20-81%).
目前的术内方法缺乏保证足够的切除边缘的精度,突出显示出未满足的临床需求.

研究的目的:

评估一种新的近红外 (NIR) 光成像探针ICG-p28的有效性,用于识别DCIS中的瘤边缘.
评估ICG-p28是否可以改善瘤边缘识别并降低DCIS模型中的复发率,与对照剂相比.
探索ICG-p28在图像引导DCIS手术中的翻译潜力.

主要方法:

开发ICG-p28,一种利用绿色氨酸 (ICG) 的探针,标有细胞透性和瘤向性图案.
在DCIS小鼠模型中测试ICG-p28用于瘤边缘的实时手术内成像.
用ICG-p28治疗的DCIS模型与仅用ICG治疗的DCIS模型之间的瘤复发率的比较.

主要成果:

使用ICG-p28对DCIS小鼠模型的实时成像显示了瘤边缘的清晰识别.
与对照剂ICG相比,ICG-p28成像方法显著改善了瘤边缘识别.
该研究显示,使用ICG-p28进行边际评估时,瘤复发率有所降低.

结论:

ICG-p28是一种有前途的成像探针,用于准确识别DCIS中的瘤边缘.
这种方法对于图像引导的DCIS手术具有显著的翻译潜力.
使用ICG-p28可能会减少重新切割的需要,并降低局部瘤复发率.

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