基础科学和病原发生学
Yang Feng1, Rafael Veiga2, Lidia Yshii3
1Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
周围适应性免疫,特别是早产的B细胞,在阿尔茨海默病 (AD) 患者中显示出显著的变化. 减少过渡性B细胞与较低的AD风险有关,突出显示它们在疾病进展中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 系统生物学 系统生物学
背景情况:
- 免疫力在阿尔茨海默氏症 (AD) 病原和进展中起着至关重要的作用.
- 周围免疫系统的变化,包括先天性和适应性免疫,在阿尔茨海默病中被研究.
- 专注于50-80岁的个体,以了解与年龄相关的AD免疫变化.
研究的目的:
- 为了检查与健康对照组相比,阿尔茨海默病 (AD) 患者的外周免疫系统变化.
- 为了确定与AD相关的先天性和适应性免疫细胞的特定变化.
- 通过机器学习评估免疫分析对阿兹海默症诊断的潜力.
主要方法:
- 利用了高维流细胞计和系统免疫学方法.
- 分析了来自184名AD患者和105名健康对照的外周血液单核细胞 (PBMC).
- 采用后勤回归,曼-惠特尼U测试,以及用于数据分析的具有交叉验证的机器学习模型.
主要成果:
- 在阿尔茨海默病患者中观察到不成熟的过渡性B细胞 (T1),过渡性B细胞和天真B细胞中的过渡性B细胞的水平降低.
- 在阿尔茨海默病患者中,天真B细胞中的非过渡性B细胞显著增加.
- 一个机器学习模型的平均AUC为0.71,表明AD检测的良好的区分能力.
结论:
- 在阿尔茨海默病中,外周适应性免疫异常主要与过早的B细胞区有关.
- 特定的B细胞子集显示了阿尔茨海默病的显著变化,表明它们参与了疾病机制.
- 对B细胞子集的免疫分析表明,它有可能成为AD的生物标志物.
相关概念视频
Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology
524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis
676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection
64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K


