一个种族敏感的混合框架用于T2D预测,具有可解释的AI和加权合奏
Karlo Abnoosian1, Rahman Farnoosh2, Hamidreza Noushkaran1
1School of Mathematics and Computer Science, Iran University of Science and Technology, Narmak, 1684613114, Tehran, Iran.
Scientific reports
|December 23, 2025
概括
一个新的框架改善了早期的2型糖尿病 (T2D) 预测,特别是在资源较少的环境中. 它解决了数据挑战,并确定了特定人群的风险因素,以更好地检测T2D.
科学领域:
- 医疗信息学 医疗信息学
- 医疗保健中的机器学习
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 构成了重大的全球健康挑战,在2021年有超过5.37亿人受到影响.
- 在低收入和中等收入国家,早期T2D预测受到数据稀缺,阶级不平衡和独特的人口风险因素的阻碍.
研究的目的:
- 开发和评估一个新的预测框架,FW-CAGIN-WCAE,旨在克服早期T2D检测的局限性.
- 提高预测准确性和可解释性,特别是在资源有限的环境中.
主要方法:
- 一个四阶段的框架:零门特征删除 (ZTFR),特征加权类适应性生成推算网络 (FW-CAGIN),加权分类器聚合集 (WCAE) 和SHAP分析.
- 使用PIDD,FHGDD和BDD数据集及其组合的嵌套五倍交叉验证.
主要成果:
- 在PIDD-BDD数据集组合中达到0.936±0.018的曲线下面面积 (AUC) 峰值.
- 从0.8028降低到0.0033.3的平均绝对误差 (MAE) 显著减少了归算.
- AUC变化率降低了36.3%,诊断几率比率 (DOR) 提高到68.4±20.5.5.
结论:
- FW-CAGIN-WCAE框架为早期T2D检测提供了一个准确,可解释和对人口敏感的方法.
- 该方法对资源有限的医疗保健机构尤其有益,为数据挑战提供了强大的解决方案.
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