与通过结肠镜检测先进腺瘤检测相关的因素,在负的多目标便DNA测试后
Ahmed M Ibrahim1, Abdulmalik Saleem2, Muhammad Salman Faisal3
1Department of Gastroenterology Trinity Health, Ann Arbor, MI, USA.
多目标便DNA (mt-sDNA) 检测结直肠癌 (CRC) 有局限性. 负面结果需要谨慎,特别是在有症状的患者中,因为近位病变可能会被遗漏,在临床上显示时需要进一步进行结肠镜检查.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 诊断医学 诊断医学
背景情况:
- 多目标便DNA (mt-sDNA) 测试是一种针对结直肠癌 (CRC) 的非侵入性查工具.
- 来自mt-sDNA测试的假阴性结果可能会推迟CRC诊断.
- 了解在阴性mt-sDNA测试后与晚期病变相关的患者因素至关重要,特别是在非标签使用的情况下.
研究的目的:
- 评估mt-sDNA检测中先进腺瘤 (AA) 和CRC的负预测值 (NPV).
- 为了确定与遗漏的晚期病变相关的患者和程序特征,在负的mt-sDNA测试后.
- 评估非标签mt-sDNA使用对测试性能的影响.
主要方法:
- 在三年内接受了结肠镜检查的具有负mt-sDNA结果的患者的回顾性研究.
- 针对晚期腺瘤 (AA) 和结直肠癌 (CRC) 的NPV计算.
- 患者人口统计学,结肠镜指示,多体特征,内镜师培训,先前结肠镜史和mt-sDNA使用 (原始深度C Cologuard版本) 的抽象.
主要成果:
- 在370名患者中,9.2%患有晚期癌前病变 (APL),其中8.4%患有AA,0.8%患有CRC.
- 检测AA与更高的息肉数量,更大的息肉大小和近邻位置 (肝曲,横直肠) 相关.
- 胃肠道出血在AA患者中更频繁 (32.3%对14.2%). 经验丰富的内镜师检测到所有的AA和CRC.
结论:
- 在负的mt-sDNA测试后,AA和CRC的条件NPV分别为91.6%和99.2%.
- 临近病变更频繁地被遗漏,强调需要进行彻底的结肠镜检查.
- 负的mt-sDNA结果需要谨慎解释,特别是在有症状的个体中,临床上建议进行结肠镜检查.
更多相关视频
28:15Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
05:58Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
Published on: August 20, 2018
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
