在自身免疫性疾病中,功能性治疗是可能的吗? 从触发根除,移植和细胞疗法的证据
Jozélio Freire de Carvalho1, Carlos Ewerton Maia Rodrigues2,3
1Núcleo de Pesquisa Em Doenças Crônicas Não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, R. Basílio da Gama, 200 - Canela, Salvador, BA, 40110-040, Brazil. jotafc@gmail.com.
Rheumatology and therapy
|December 23, 2025
概括
对自身免疫性疾病 (AID) 的功能治愈是可能的,通过有针对性的干预措施,如触发器根除或免疫重置. 需要进一步的研究来标准化定义,并将这些策略整合到AIDs的常规护理中.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
背景情况:
- 自免疫性疾病 (AID) 传统上被认为是无法治愈的.
- 特殊情况可能允许在AID中持续缓解或功能治愈.
- 功能性治愈被定义为持续的临床和实验室缓解,没有免疫抑制.
研究的目的:
- 审查关于在自身免疫性疾病中实现持续缓解或功能治愈的证据.
- 评估治疗策略,包括传染性触发器根除,免疫恢复,细胞疗法,环境/营养策略和副瘤综合征.
主要方法:
- 在主要数据库中按照PRISMA指南进行系统审查.
- 包括试验,元分析,队列,病例系列和病例报告.
- 严格的定义适用于缓解和功能治愈 (≥12个月的治疗).
主要成果:
- 根除Helicobacter pylori显示出强有力的证据,证明免疫血栓塞缩性紫外线的缓解.
- 自主造血干细胞移植 (HSCT) 改善了系统性硬化症的生存率.
- 抗CD19的CAR-T疗法在B细胞介导的AID中诱导了深度缓解.
- 瘤综合征中的瘤控制往往导致自身免疫缓解.
结论:
- 在特定情况下,通过触发器去除,免疫恢复或免疫衰竭,可以在艾滋病中实现功能治愈.
- 标准化定义和预测生物标志物对于推进这种范式至关重要.
- 为了将这些策略纳入临床实践,需要进行长期的受控试验.
关键词:
在Helicobacter Pylori的研究中,自身免疫性疾病是一种自身免疫性疾病.自主造血干细胞移植自主造血干细胞移植在CART-T中,使用CART-T.身体以外的光电场.功能疗法是一种功能疗法.麻性综合征 麻性综合征植物性饮食是一种植物性饮食.持续的缓解持续的缓解维生素D 维生素D是一种维生素.更多相关视频
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