在Aspergillus fumigatus中地理结构化的基因型和耐药性聚类
Won-Bok Kim1, Dukhee Nho2,3, Sung-Yeon Cho2,3
1Genes Laboratories Inc, Yongin-si, Gyeonggi-do, Republic of Korea.
概括
多部位变数串联重复 (MLVA) 排版揭示了Aspergillus fumigatus的独特全球集群. 亚醇耐药性突变集中在特定的集群中,这表明局部出现和国家层面的丰富.
科学领域:
- 医学真菌学 医学真菌学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 阿斯伯吉勒斯烟雾菌是全球重要的真菌病原体.
- 了解其种群结构和醇耐药性对于公众健康至关重要.
- 多位数变量数串联重复 (MLVA) 类型是分子监控的宝贵工具.
研究的目的:
- 为了分析Aspergillus fumigatus的全球种群结构.
- 调查与醇耐药性相关的突变的地理分布 (TR34/TR46).
- 评估MLVA类型对真菌分子监测的有用性.
主要方法:
- 分析了498个全球Aspergillus fumigatus分离物.
- 包括155个新基因型的韩国菌株.
- 应用多位置变量数串联重复 (MLVA) 打字的应用.
主要成果:
- 识别了广泛的基因型多样性和四个不同的植物地理集群.
- 观察在特定集群中集中的与耐药性相关的突变 (TR34/TR46).
- 德国,韩国和中国的抗性突变在国家层面的丰富的证据.
结论:
- 阿斯伯吉拉斯烟虫 (Aspergillus fumigatus) 的种群具有地理结构.
- 局部出现的醇耐药性得到了研究结果的支持.
- MLVA类型是有效的分子监测,特别是当全基因组测序是有限的.
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