环境因素与白细胞概况对菌根性肺部疾病的相互作用影响:一个病例控制研究
Xuan Ngoc Tran1, Kuan-Jen Bai2, Chi-Won Suk2
1International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
BMC infectious diseases
|December 23, 2025
概括
湿度,温度和PM2.5等环境因素会影响真菌细菌肺部疾病. 白细胞计数改变了这些效应,影响了结核病和NTM疾病的风险.
科学领域:
- 环境科学环境科学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 菌根性肺部疾病,包括耐药结核病 (DS-TB),多耐药结核病 (MDR-TB) 和非结核性菌根 (NTM) 疾病,对全球健康构成重大挑战.
- 研究环境因素及其与宿主免疫反应的相互作用对于理解疾病的发病因子和开发有效的控制策略至关重要.
研究的目的:
- 为了检查相对湿度 (RH),温度和细颗粒物 (PM2.5) 与白细胞 (WBC) 计数对肺部DS-TB,MDR-TB和NTM疾病的相互作用效应.
- 探索环境暴露和真菌细菌肺部疾病之间的潜在非线性关联.
主要方法:
- 进行了一项病例控制研究,涉及1398名参与者 (409例,989例对照).
- 个人对RH,温度和PM2.5的暴露被使用辐射基函数插值评估.
- 使用后勤回归和通用添加模型来分析与WBC的关联和相互作用效应.
主要成果:
- 较高的平均RH与DS-TB的几率比率下降有关.
- 增加的每日温度差异和PM2.5与所有真菌细菌疾病组的更高赔率比率有关.
- 中性细胞计数调节了温度对NTM疾病的影响,而淋巴细胞计数则影响了DS-TB和MDR-TB的温度影响.
结论:
- 宿主免疫特征,特别是白细胞计数,显著改变了短期环境暴露 (例如温度) 和真菌细菌肺部疾病之间的关系.
- 了解这些复杂的相互作用对于推进结核病预防和早期检测策略至关重要.
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