红细胞分布宽度和相关指数与高血压儿童的目标器官损伤相关
Arife Uslu Gökceoğlu1, Nesrin Taş2, Nuriye Boduç Bolu3
1Department of Pediatric Nephrology, Alanya Alaaddin Keykubat University, Faculty of Medicine, Antalya, Türkiye. arifeuslu2001@yahoo.com.
BMC pediatrics
|December 23, 2025
概括
红细胞分布宽度 (RDW) 和红细胞分布宽度与血小板计数比率 (RPR) 在患有初级高血压的儿童中可能表明目标器官损伤,特别是左心室缩 (LVH). 在这个人群中,男性性别是LVH的危险因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血液学 血液学 血液学
- 高血压研究 高血压研究
背景情况:
- 儿童的初级高血压是一个越来越令人担忧的问题.
- 目标器官损伤是儿科高血压的重要并发症.
- 了解早期损害标志物对于及时干预至关重要.
研究的目的:
- 调查红细胞分布宽度 (RDW) 和相关指数与患有初级高血压的儿童的目标器官损伤之间的关联.
- 探索 RDW 和新型衍生指数 (RPR,RAR) 作为潜在生物标志物的临床影响.
主要方法:
- 一项回顾性横截面研究分析了219名高血压儿童和57名对照儿童的数据.
- 收集的数据包括人口统计,BMI,血红蛋白,RDW,白细胞计数,血小板计数和白蛋白.
- 通过心声学,视网膜检查和尿液分析评估目标器官损伤;计算RPR和RAR.
主要成果:
- 在高血压儿童中,增加的RDW和RPR显著与左心室缩 (LVH) 相关.
- 男性的性别是LVH的重要风险因素.
- 肥胖儿童的白细胞数量较高,但RDW和RAR与BMI无关;RPR在正常BMI患者中较高.
结论:
- RDW和RPR显示出在儿科高血压中检测目标器官损伤 (LVH) 的生物标志物潜力.
- 在这种情况下,RAR的实用性有限.
- 血液学参数提供了有关儿童心血管风险和肥胖相关炎症的见解.
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