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Updated: Jan 8, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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达鲁纳维尔的模拟前体向多发性骨髓瘤和CLL中的线粒体代谢

Marisabel Mecca1, Marzia Sichetti1, Enrico La Spina2

  • 1Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture (PZ), 85028, Italy.

Cancer cell international
|December 23, 2025
PubMed
概括

两种新型HIV蛋白酶抑制剂前体BupM-NH2和BnpM-NH2通过抑制线粒体呼吸和自细胞,对多发性骨髓瘤 (MM) 和慢性淋巴细胞白血病 (CLL) 细胞表现出显著的细胞毒性. 这些化合物显示出克服血液性恶性瘤中药物耐药性的前景.

关键词:
自自是一种自的过程.慢性淋巴性白血病慢性淋巴性白血病艾滋病毒蛋白酶抑制剂 艾滋病毒蛋白酶抑制剂线粒体中的线粒体.多发性骨髓瘤是一种多发性骨髓瘤.

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