Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

7.1K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.1K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.5K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

3.9K
3.9K
DNA as a Genetic Template02:05

DNA as a Genetic Template

27.3K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
27.3K
DNA as a Genetic Template02:05

DNA as a Genetic Template

9.2K
9.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Efficient and Tidy Manipulation of Annotated Matrix Data with plyxp.

bioRxiv : the preprint server for biology·2026
Same author

Stem cells as an essential mediator of the exercise-tumorigenesis link.

Nature reviews. Cancer·2026
Same author

Preemptive cardioprotection with a small molecule in rodents that suppresses genes predictive of heart failure.

Science advances·2026
Same author

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.

Science (New York, N.Y.)·2026
Same author

MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.

Molecular psychiatry·2026
Same journal

Advances and challenges of splicing prediction with AI.

Nature genetics·2026
Same journal

Non-coding variant prioritization based on cell type, developmental stage and evolutionary constraint.

Nature genetics·2026
Same journal

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same journal

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

Nature genetics·2026
Same journal

Taking apart the DNA-methylation clock with an epigenetic progeria syndrome.

Nature genetics·2026
Same journal

Decoding common and rare noncoding variant effects across cellular and developmental contexts.

Nature genetics·2026
查看所有相关文章
  1. 首页
  3. 使用生成性ai框架设计合成监管元素 Dna-扩散.
  1. 首页
  3. 使用生成性ai框架设计合成监管元素 Dna-扩散.

相关实验视频

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.8K

使用生成性AI框架设计合成监管元素 DNA-扩散.

Lucas Ferreira DaSilva1,2, Simon Senan2,3, Judith F Kribelbauer-Swietek4,5,6

  • 1Department of Pathology, Harvard Medical School, Boston, MA, USA.

Nature genetics
|December 24, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

人工智能框架DNA-Diffusion设计了具有细胞类型特定活动的紧基因调节元件. 这促进了合成生物学和基因疗法的发展,使精确的基因控制成为可能.

更多相关视频

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.7K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.7K

相关实验视频

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.8K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.7K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.7K

科学领域:

  • 基因组学就是基因组学.
  • 合成生物学 合成生物学
  • 人工智能的人工智能

背景情况:

  • 通过调节元件精确控制基因表达是一个关键的挑战.
  • 现有的方法难以平衡功能活动,细胞类型特异性和序列多样性.

研究的目的:

  • 介绍DNA-Diffusion,一种用于设计新型监管元素的生成性AI框架.
  • 通过紧的合成元素实现细胞类型特定的基因表达控制.

主要方法:

  • 开发了DNA-Diffusion,这是一种基于DNA可访问性数据进行训练的AI框架.
  • 产生了模仿内源转录因子结合的200个基对合成元素.
  • 用STARR-seq在三个细胞系和EXTRA-seq用于内源基因调节的验证元素.

主要成果:

  • 通过DNA扩散产生了具有增强细胞类型特异性的紧元素.
  • 合成元素回顾了内源转录因子结合语法.
  • 成功地在原生环境中重新激活了AXIN2基因,证明了功能调制.

结论:

  • 在设计监管元素方面,DNA-Diffusion的性能优于现有的计算方法.
  • 这一框架对于在基因治疗中设计精确的基因调节至关重要.
  • 能够在理解基因调节和开发新型治疗策略方面取得进展.