在消化系统癌症中,TGF-β信号和长非编码RNA之间的相互作用:机制和生物影响
Penghui Li1, Di Huang2, Xinyu Gu3
1Department of Gastrointestinal Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471000, Henan, China.
Human cell
|December 24, 2025
概括
长非编码RNAs (lncRNAs) 和转化生长因子β (TGFβ) 信号在消化系统癌症中相互作用. 本综述探讨了它们在癌症进展中的作用,作为生物标志物的潜力以及治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 转化生长因子β (TGFβ) 信号通路在细胞过程中至关重要,并与消化系统癌症有关.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症发育和进展中的调节作用.
- TGFβ信号传递和lncRNAs之间的相互作用显著影响消化系统癌症的行为.
研究的目的:
- 审查消化系统癌症中TGFβ信号通路和lncRNAs之间的复杂相互作用.
- 阐明这些相互作用在癌症进展,转移和临床特征中的作用.
- 突出针对lncRNA-TGFβ轴的诊断,预后和治疗潜力.
主要方法:
- 对研究TGFβ信号传递和消化系统癌症中的lncRNA进行研究的文献综述.
- 对lncRNAs在癌症生物学中的功能性作用的研究分析,包括EMT,瘤生长和免疫反应.
- 综合与生物标志物潜力和针对lncRNA-TGFβ轴的治疗策略相关的发现.
主要成果:
- 与TGFβ-Smad通路相关的dysregulated lncRNA表达与消化系统癌症的临床特征相关.
- lncRNAs影响关键的生物功能,如上皮细胞转变为介质细胞转变 (EMT),瘤生长和免疫逃避.
- 这些lncRNA与TGFβ-Smad通路分子相互作用,影响基因转录和细胞行为.
结论:
- lncRNA-TGFβ轴在消化系统癌症的进展和转移中发挥着关键作用.
- 改变的lncRNA表达作为一个潜在的生物标志物用于早期检测和预后的消化系统癌症.
- 针对lncRNA-TGFβ相互作用,为消化系统癌症提供了一个有前途的新疗法策略.
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