与波士顿波多黎各人健康研究中的质子抑制剂使用相关的肠道微生物变异
Deepika Dinesh1,2, Xochitl C Morgan3,4, Hanseul Kim3,5
1Department of Public Health, University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Pharmacology research & perspectives
|December 24, 2025
概括
质子抑制剂 (PPI) 改变了波多黎各人的肠道细菌,丰富了像Streptococcus这样的口腔典型物种. 这项研究强调了与PPI在这个人群中的使用相关的潜在微生物组变化.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 人口健康 人口健康
背景情况:
- 质子抑制剂 (PPI) 广泛用于胃肠道疾病.
- 众所周知,PPI会影响肠道微生物群,但这在不同人群中还没有得到充分研究.
- 波多黎各人报告高PPI使用,需要研究相关的微生物组变化.
研究的目的:
- 调查PPI使用与波多黎各人的肠道微生物组成之间的关联.
- 在这一群体中识别受PPI影响的特定细菌种群和功能途径.
- 将结果与非西班牙裔队列进行比较,以探索与种族相关的差异.
主要方法:
- 来自波士顿 - 波多黎各健康研究 (BPRHS) 309名参与者的便样本的分析.
- 基因组分析分析,以评估肠道微生物种群和功能途径.
- 包括多变量线性建模 (MaAsLin2) 和随机森林分类在内的统计分析.
- 与健康专业人员随访研究 (HPFS) 的数据进行比较.
主要成果:
- 112 (36%) 的BPRHS参与者报告使用PPI.
- 使用PPI的患者表现出口腔典型细菌的丰富,包括链球菌种 (S. parasanguinis,S. anginosus,S. salivarius) 和Rothia mucilaginosa.
- 与链球菌,乳球菌和肠球菌相关的功能途径主要与PPI使用有关.
结论:
- 在波多黎各人中,使用PPI与肠道微生物组合的显著改变有关.
- 口腔典型类型的丰富表明PPI诱导的微生物组变化的潜在机制.
- 需要进一步的研究,以了解PPI对肠道微生物群的影响的长期健康影响和种族差异.
相关概念视频
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
815
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
815
Peptic Ulcer Disease I: Introduction
707
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
707
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K
Stomach pH Regulation
7.0K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
7.0K
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
162
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
162
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
400
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
400


