对成年患有过敏性鼻炎的患者使用抗组胺剂的成本效益
Jefferson Antonio Buendía1, Diana Guerrero Patino2
1Departamento de Farmacología y Toxicología, Facultad de Medicina, Grupo de Investigación en Farmacología y Toxicología, Universidad de Antioquia, Carrera 51D #62-29, Medellín, Colombia. jefferson.buendia@gmail.com.
Cost effectiveness and resource allocation : C/E
|December 24, 2025
概括
对于哥伦比亚间歇性过敏鼻炎的成年人来说, cetirizine 和 fexofenadine 是最具成本效益的口服抗胰岛素药物. 这些选项提供了高的净货币收益,使它们成为管理AR的有价值选择.
科学领域:
- 药物经济学 药物经济学
- 过敏和免疫学 过敏和免疫学
- 卫生经济学 卫生经济学
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍存在的全球疾病,带来了大量的医疗费用和降低了生活质量.
- 建议使用鼻腔内皮质类固醇,但口服抗胰岛素在低收入和中等收入国家很常见.
- 这项研究的重点是哥伦比亚间歇性AR新一代口服H1抗胰岛素的成本效益.
研究的目的:
- 在哥伦比亚,对患有间歇性过敏性鼻炎的成年人进行新一代口服H1抗胰岛素的成本效益分析.
- 根据临床有效性和不良事件,比较各种口服抗胰岛素的成本效益.
- 为了确定哥伦比亚环境中间歇性AR最经济可行的治疗选择.
主要方法:
- 用一个28天的决策树模型来比较多种抗胰岛素的成本和质量调整寿命年 (QALY).
- 关于临床有效性和不良事件的数据来源于系统性审查和网络元分析.
- 净货币收益 (NMB) 用哥伦比亚的支付意愿值计算,并进行敏感性分析以解决不确定性.
主要成果:
- 确定了10毫克的利津和180毫克的费克索芬阿丁是唯一具有优越NMB的非主导策略.
- 确定性分析表明, cetirizine 的总成本较低,每 QALY 的 ICER 为 349.62 美元.
- 概率分析支持fexofenadine在各种值中具有成本效益,而 cetirizine在较低的值中仍然具有竞争力.
结论:
- 塞蒂里辛10毫克和fexofenadine 180毫克是哥伦比亚中断性过敏性鼻炎的成年人最具成本效益的口服H1抗组胺药物.
- 这两种药物都显示出高净货币效益,并且在敏感性分析中没有占据主导地位.
- 这些发现为管理哥伦比亚间歇性AR提供了有价值的经济指导.
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